Cytotoxic Effects of Cisplatin and Carboplatin Loaded Albumin Nanoparticles on Breast Cancer Cells

Objective: This study aims to investigate and compare the anticancer effects of carboplatin cisplatin, frequently used in cancer treatment, by loading them on albumin nanocarrier. Materials Methods: Carboplatin (CP) Cisplatin (Cis) loaded nanoparticles were synthesized using ultrasonication as CP-NPs Cis-NPs, respectively. Nanoparticle size distribution evaluated Dynamic light scattering (DLS). Cytotoxicities NPs MDA-MB-231 MCF-7 breast cells HUVEC MTT test their morphological images compared. Results: While average was around 2-3 nm, Cis-NPs 7-8 nm. It observed that both groups homogeneously dispersed. According cytotoxicity results, more cytotoxic cells. In addition, showed significant MCF-7, cells, while low detected normal The treated compared with untreated statistical significance calculated P<0.01 for Cis-NPs. Conclusions: Abumin-based high they have healthy making promising treatment.